OUR PROGRAM
Bayer has joined forces with world-class academic institutions and other pharma companies as part of the Structural Genomics Consortium (SGC):
In an Open Science effort we identify chemical probes for novel drug discovery targets and make them openly available for academic labs who can use these probes without any restrictions to study the disease relevance of such novel targets.
This joint effort is for the benefit of patients as high-quality science forms the basis for the next generation of therapeutics. The program is also part of the European IMI project EUbeOPEN.
OUR OFFER
A set of well-characterized compounds (with corresponding negative probe). Browse the list below!
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Probe Name: BAY-3827 Negative Pair: BAY-974 |
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Probe Name: BAY-850 Negative Pair: BAY-460 |
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
ACS Chem. Biol., 12 (11): 2730-2736mical Structure and Unusual Mode of Action
ACS Chem. Biol., 12 (11): 2730-2736
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Probe Name: |
tbd
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Probe Name: BAY-299 Negative Pair: BAY-364 |
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60(9): 4002–4022
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Probe Name: |
tbd
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Probe Name: BAY-474 Negative Pair: BAY-827 |
Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
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Probe Name: |
tbd
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Probe Name: BAY-885 Negative Pair: BAY-693 |
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem. 2018 Dec 18
| Probe Name: BAY-6672 Negative Pair: BAY-403 (racemate) |
manuscript submitted
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Probe Name: BAY-876 Negative Pair: BAY-588 |
Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-576.
ChemMedChem 11(29): 2261-2271cal Structure and Unusual Mode of ActionChem. Biol., 12 (11): 2730-2736
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Probe Name: BAY-784 Negative Pair: BAY-786 |
Discovery and First Structural Disclosure of an Oral GnRH Receptor Antagonist and ist Characterization in Vitro, in Animals and Humans
19th RSC / SCI Medicinal Chemistry Symposium 2017, Cambridge, UK
Olaf Panknin, Andrea WagenfeldUK
Olaf Panknin, Andrea Wagenfeld
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Probe Name: BAY-678 Negative Pair: (S)-enantiomer is inactive |
Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyradazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
ChemMedChem 11(2): 199-206
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Probe Name: BAY-7598 Negative Pair: BAY-694 |
Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311
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Probe Name: BAY-707 Negative Pair: BAY-604 |
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. J Med Chem. 2018 Mar 22;61(6):2533-2551
Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311
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Probe Name: |
tbd
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Probe Name: |
Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
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Probe Name: |
tbd
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Probe Name: BAY-598 Negative Pair: BAY-369 |
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-
Based in Vivo Probe (BAY-598)
for the Protein Lysine Methyltransferase SMYD2.
Journal of Medicinal Chemistry, 59(10): 4578-600
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Probe Name: BAY-6035 Negative Pair: BAY-211 |
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Probe Name: |
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25
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Probe Name: BAY-985 Negative Pair: BAY-440 |
tbd
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Probe Name: BAY-826 Negative Pair: BAY-309 |
Novel TIE-2 Inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.
J Neurochem 140;170-182
Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
| Probe Name: BAY-390 Negative Pair: BAY-9897 |
manuscript submitted
