YOUR ORDER

can be placed through

OUR PROGRAM

Bayer has joined forces with world-class academic institutions and other pharma companies as part of the Structural Genomics Consortium (SGC):

 

In an Open Science effort we identify chemical probes for novel drug discovery targets and make them openly available for academic labs who can use these probes without any restrictions to study the disease relevance of such novel targets.

 

This joint effort is for the benefit of patients as high-quality science forms the basis for the next generation of therapeutics. The program is also part of the European IMI project EUbeOPEN.

 

OUR OFFER

A set of well-characterized compounds (with corresponding negative probe). Browse the list below!

AMPK-RSK1
Probe Name:
BAY-3827

Negative Pair:
BAY-974

ATAD2
Probe Name:
BAY-850

Negative Pair:
BAY-460

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
ACS Chem. Biol., 12 (11): 2730-2736mical Structure and Unusual Mode of Action

ACS Chem. Biol., 12 (11): 2730-2736

 

Probe Name:
BAY-069

Negative Pair:
BAY-771

tbd

BRPF2/TAF1
Probe Name:
BAY-299

Negative Pair:
BAY-364

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60(9): 4002–4022

 

Probe Name:
BAY-3153

Negative Pair:
BAY-173

tbd

cMET
Probe Name:
BAY-474

Negative Pair:
BAY-827

Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311

Complex1

Probe Name:
BAY-179

Negative Pair:
BAY-070

tbd

ERK5
Probe Name:
BAY-885

Negative Pair:
BAY-693

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem. 2018 Dec 18

  Probe Name:
BAY-6672

Negative Pair:
BAY-403
(racemate)

manuscript submitted

GLUT1
Probe Name:
BAY-876

Negative Pair:
BAY-588

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-576.
ChemMedChem 11(29): 2261-2271cal Structure and Unusual Mode of ActionChem. Biol., 12 (11): 2730-2736

GNRH-R
Probe Name:
BAY-784

Negative Pair:
BAY-786

Discovery and First Structural Disclosure of an Oral GnRH Receptor Antagonist and ist Characterization in Vitro, in Animals and Humans
19th RSC / SCI Medicinal Chemistry Symposium 2017, Cambridge, UK
Olaf Panknin, Andrea WagenfeldUK

Olaf Panknin, Andrea Wagenfeld

HNE
Probe Name:
BAY-678

Negative Pair:
(S)-enantiomer is inactive

Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyradazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model.
ChemMedChem 11(2): 199-206

MMP12
Probe Name:
BAY-7598

Negative Pair:
BAY-694

Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311

MTH1
Probe Name:
BAY-707

Negative Pair:
BAY-604

Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design.  J Med Chem. 2018 Mar 22;61(6):2533-2551

Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311

P2X4

Probe Name:
BAY-1797

Negative Pair:
BAY-207

tbd

PAR1

Probe Name:
BAY-386

Negative Pair:
BAY-448

Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311

 

Probe Name:
BAY-549

Negative Pair:
BAY-4900

tbd

SMYD2
Probe Name:
BAY-598

Negative Pair:
BAY-369

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-
Based in Vivo Probe (BAY-598)
for the Protein Lysine Methyltransferase SMYD2.
Journal of Medicinal Chemistry, 59(10): 4578-600

SMYD3
Probe Name:
BAY-6035

Negative Pair:
BAY-211

P2X4

Probe Name:
BAY-293

Negative Pair:
BAY-294

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25

TBK1-IKKe
Probe Name:
BAY-985

Negative Pair:
BAY-440

tbd

Tie-DDR
Probe Name:
BAY-826

Negative Pair:
BAY-309

Novel TIE-2 Inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.
J Neurochem 140;170-182

Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311

  Probe Name:
BAY-390

Negative Pair:
BAY-9897

manuscript submitted